Pathoplexus is an open-source database dedicated to the efficient sharing of human viral pathogen genomic data, fostering global collaboration and public health response. Users can choose to share their data openly, or with time-limited protections to help ensure proper attribution and credit. It integrates smoothly with existing INSDC-member databases (NCBI, ENA, and DDBJ), enabling data that’s ‘open’ on Pathoplexus to also appear on INSDC, and INSDC data to be accessed through Pathoplexus.