HAMAP family: MF

General rule information

Accession	MF_01959
Dates	12-MAY-2006 (Created) 30-JUN-2008 (Last updated, Version 15)

Data class

Protein

Predictors

HAMAP; MF_01959; [distribution of match scores in UniProtKB];[seed alignment for MF_01959]

Propagated annotation

Identifier, protein and gene names

Identifier

CCME

Protein name

RecName:	Full=Cytochrome c-type biogenesis protein ccmE;
AltName:	Full=Cytochrome c maturation protein E;
AltName:	Full=Heme chaperone ccmE;

Gene name

ccmE, cycJ

Comments

FUNCTION: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by ccmC and transfers the heme to apo-cytochromes in a process facilitated by ccmF and ccmH (By similarity).

case <Property:Membrane=1>

SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (Potential).

else case <Property:Membrane=2>

SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential).

end case

SIMILARITY: Belongs to the ccmE/cycJ family.

Cross-references

Pfam	PF03100; CcmE; 1;

Keywords

Cytochrome c-type biogenesis, Heme, Cell membrane.

case <Property:Membrane=2>

Cell inner membrane.

end case

Iron, Membrane, Metal-binding, Transmembrane, Signal-anchor.

Gene Ontology

GO:0017003; Biological process: protein-heme linkage.
GO:0005886; Cellular component: plasma membrane.

Features

`From: CCME_ECOLI (P69490)`
`Key`	`From`	`To`	`Description`	`Condition`	`FTGroup`
`TOPO_DOM`	`Nter`	`8`	`Cytoplasmic (Potential)`
`TRANSMEM`	`9`	`29`	`Signal-anchor for type II membrane protein (Potential)`

case <Property:Membrane=1>

`Key`		`From`		`To`		`Description`		`Condition`		`FTGroup`
`TOPO_DOM`		`30`		`Cter`		`Extracellular (Potential)`

end case

case <Property:Membrane=2>

`Key`		`From`		`To`		`Description`		`Condition`		`FTGroup`
`TOPO_DOM`		`30`		`Cter`		`Periplasmic (Potential)`

end case

`Key`	`From`	`To`	`Description`	`Condition`	`FTGroup`
`METAL`	`134`	`134`	`Iron (heme axial ligand) (By similarity)`	`Y`
`BINDING`	`130`	`130`	`Heme (covalent; via pros nitrogen) (By similarity)`	`H`

Additional information

Size range:	128-181 amino acids
Related UniRules:	None
Template:	P69490 (CCME_ECOLI); Q8EK44 (CCME_SHEON): [Recover all]
Scope:	Bacteria; Deinococci Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEPF, RHIEC, SALCH, SALPA, SALTI, SALTY, SILPO, XANAC, XANC5, XANC8, XANCP, XANOM, XANOR
Plasmid encoded:	in RALEH, RHIEC, RHIET, SILPO
Comments:	In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene.

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