Accession	MF_01953
Dates	10-APR-2006 (Created) 24-JUL-2008 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_01953; [distribution of match scores in UniProtKB];[seed alignment for MF_01953]

Identifier

URE1

Protein name

RecName: Full=Urease subunit alpha; EC=3.5.1.5; AltName: Full=Urea amidohydrolase subunit alpha;

Gene name

ureC

Protein name

RecName: Full=Urease subunit beta; EC=3.5.1.5; AltName: Full=Urea amidohydrolase subunit beta;

Gene name

ureB

CATALYTIC ACTIVITY: Urea + H(2)O = CO(2) + 2 NH(3).

COFACTOR: Binds 2 nickel ions per subunit (By similarity).

PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.

SUBUNIT: Heterohexamer of 3 ureA (alpha) and 3 ureB (beta) subunits (By similarity).

SUBUNIT: Heterohexamer of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits (By similarity).

SUBUNIT: May form a heterohexamer of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits. May also form a heterotrimer of ureA (gamma), ureB (beta) and ureC (alpha) subunits. Three heterotrimers associate to form the active enzyme (By similarity).

SUBUNIT: Heterotrimer of ureA (gamma), ureB (beta) and ureC (alpha) subunits. Three heterotrimers associate to form the active enzyme (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

PTM: Carbamylation allows a single lysine to coordinate two nickel ions (By similarity).

SIMILARITY: Belongs to the urease family.

CAUTION: The orthologous protein is known as the alpha subunit (ureC) in most other bacteria.

PROSITE	PS01120; UREASE_1; 1; PS00145; UREASE_2; 1;
Pfam	PF01979; Amidohydro_1; 1; PF00449; Urease_alpha; 1;
PRINTS	PR01752; UREASE; 1;
TIGRFAMs	TIGR01792; urease_alph; 1;

Cytoplasm, Hydrolase.

Metal-binding, Nickel.

GO:0009039; Molecular function: urease activity.

GO:0016151; Molecular function: nickel ion binding.

GO:0019627; Biological process: urea metabolic process.
GO:0005737; Cellular component: cytoplasm.

From: URE1_KLEAE (P18314)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		320		320		Proton donor (By similarity)		H
METAL		134		134		Nickel 2 (By similarity)		H		2
METAL		136		136		Nickel 2 (By similarity)		H		2
METAL		217		217		Nickel 1; via carbamate group (By similarity)		K		1
METAL		217		217		Nickel 2; via carbamate group (By similarity)		K		2
METAL		246		246		Nickel 1 (By similarity)		H		1
METAL		272		272		Nickel 1 (By similarity)		H		1
METAL		360		360		Nickel 2 (By similarity)		D		2
BINDING		219		219		Substrate (By similarity)		H
MOD_RES		217		217		N6-carboxylysine (By similarity)		K

Size range:	556-598 amino acids
Related UniRules:	None
Template:	P18314 (URE1_KLEAE); P77837 (URE1_BACSU); P69996 (URE1_HELPY): [Recover all]
Scope:	Bacteria Archaea; Sulfolobales Archaea; Halobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BRUA2, BRUAB, BRUME, BRUSU, ECO57, PSEU2, STRAW, STRCO
Plasmid encoded:	in CLOPE, ECOLX, HALMA