HAMAP family: MF

General rule information

Accession	MF_01844
Dates	22-APR-2008 (Created) 4-DEC-2008 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01844; [distribution of match scores in UniProtKB];[seed alignment for MF_01844]

Propagated annotation

Identifier, protein and gene names

Identifier

NHAA

Protein name

RecName:	Full=Na(+)/H(+) antiporter nhaA;
AltName:	Full=Sodium/proton antiporter nhaA;

Gene name

nhaA

Comments

FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons (By similarity).

case <Property:Membrane=1>

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

end case

SIMILARITY: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family.

Cross-references

Pfam	PF06965; Na_H_antiport_1; 1;
TIGRFAMs	TIGR00773; NhaA; 1;

case not <OC:Escherichia> and not <OC:Shigella>

General

Transmembrane; -; 9-12; trigger=Yes;

end case

Keywords

Antiport, Cell membrane.

case <Property:Membrane=2>

Cell inner membrane.

end case

Ion transport, Membrane, Sodium, Sodium transport, Transmembrane, Transport.

Gene Ontology

GO:0015297; Molecular function: antiporter activity.
GO:0015081; Molecular function: sodium ion transmembrane transporter activity.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.

Features

case <OC:Escherichia> or <OC:Shigella>

`From: NHAA_ECOLI (P13738)`
`Key`	`From`	`To`	`Description`	`Condition`	`FTGroup`
`TOPO_DOM`	`Nter`	`11`	`Cytoplasmic (By similarity)`
`TRANSMEM`	`12`	`30`	`By similarity`
`TOPO_DOM`	`31`	`58`	`Periplasmic (By similarity)`
`TRANSMEM`	`59`	`85`	`By similarity`
`TOPO_DOM`	`86`	`94`	`Cytoplasmic (By similarity)`
`TRANSMEM`	`95`	`116`	`By similarity`
`TOPO_DOM`	`117`	`120`	`Periplasmic (By similarity)`
`TRANSMEM`	`121`	`143`	`By similarity`
`TOPO_DOM`	`144`	`149`	`Cytoplasmic (By similarity)`
`TRANSMEM`	`150`	`175`	`By similarity`
`TOPO_DOM`	`176`	`181`	`Periplasmic (By similarity)`
`TRANSMEM`	`182`	`200`	`By similarity`
`TOPO_DOM`	`201`	`204`	`Cytoplasmic (By similarity)`
`TRANSMEM`	`205`	`218`	`By similarity`
`TOPO_DOM`	`219`	`222`	`Periplasmic (By similarity)`
`TRANSMEM`	`223`	`236`	`By similarity`
`TOPO_DOM`	`237`	`246`	`Cytoplasmic (By similarity)`
`TRANSMEM`	`247`	`271`	`By similarity`
`TOPO_DOM`	`272`	`289`	`Periplasmic (By similarity)`
`TRANSMEM`	`290`	`311`	`By similarity`
`TOPO_DOM`	`312`	`326`	`Cytoplasmic (By similarity)`
`TRANSMEM`	`327`	`350`	`By similarity`
`TOPO_DOM`	`351`	`356`	`Periplasmic (By similarity)`
`TRANSMEM`	`357`	`382`	`By similarity`
`TOPO_DOM`	`383`	`Cter`	`Cytoplasmic (By similarity)`

end case

Additional information

Size range:	376-503 amino acids
Related UniRules:	None
Template:	P13738 (NHAA_ECOLI); O85187 (NHAA_VIBCH); Q56725 (NHAA_VIBPA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: <Unknown>, <Thioredoxin domain>; Cter: <Thioredoxin domain>, <Peptidase S49>
Duplicate:	in ACICJ, ARCB4, CAMFF, CAMHC, CAMJ8, CAMJD, CAMJE, CAMJJ, CAMJR, CLAM3, CLOB8, DEIGD, ERYLH, FLAJ1, FRAAA, HELHP, KINRD, KLEP7, MAGSM, MYCGI, MYCSJ, MYCSK, MYCSS, MYCVP, MYXXD, NOCSJ, NOVAD, OCHA4, PELCD, PELPD, PSE14, PSEA6, PSEP1, PSEPK, PSESM, PSEU2, PSYIN, RHOSR, SACD2, SACEN, SALAI, SALTO, SHEDO, SORC5, STRCO, VIBVU
Plasmid encoded:	in ACICJ, DEIGD, KLEP7, NITHX, RHIME
Comments:	Some of the Rickettsiales are shorter than orthologs; sequences are not shown in alignment and not taken into account in size range.

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