ExPASy Proteomics Server

Accession	MF_01608
Dates	18-FEB-2005 (Created) 25-NOV-2009 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_01608; [distribution of match scores in UniProtKB];[seed alignment for MF_01608]

Names

CoA-diS-reduct

Identifier

CDR

Protein name

RecName: Full=Coenzyme A disulfide reductase; Short=CoA-disulfide reductase; Short=CoADR; EC=1.8.1.14;

Gene name

cdr

FUNCTION: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide (By similarity).

CATALYTIC ACTIVITY: 2 CoA + NAD(P)(+) = CoA-disulfide + NAD(P)H.

COFACTOR: Binds 1 FAD per subunit (By similarity).

SUBUNIT: Homodimer (By similarity).

DOMAIN: Contains 2 FAD binding domains and a single NADPH binding domain (By similarity).

MISCELLANEOUS: Reduction of disulfides occurs by a thiol-disulfide exchange reaction, but involves only a single catalytic cysteine residue that forms a stable mixed disulfide with CoA during catalysis (By similarity).

SIMILARITY: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

Pfam	PF00070; Pyr_redox; 1; PF02852; Pyr_redox_dim; 1;
PRINTS	PR00368; FADPNR; 1; PR00411; PNDRDTASEI; 1;

FAD, Flavoprotein, NADP, Oxidoreductase, Redox-active center.

GO:0050451; Molecular function: CoA-disulfide reductase activity.
GO:0050660; Molecular function: FAD binding.
GO:0050661; Molecular function: NADP or NADPH binding.
GO:0006467; Biological process: protein thiol-disulfide exchange.

From: CDR_STAA8 (O52582)
Key		From		To		Description		Condition		FTGroup
NP_BIND		8		33		FAD (By similarity)
NP_BIND		151		166		NADP (By similarity)
NP_BIND		267		277		FAD (By similarity)
ACT_SITE		43		43		Nucleophile (By similarity)		C
ACT_SITE		43		43		Redox-active (By similarity)		C
BINDING		15		15		Substrate (By similarity)		T
BINDING		19		19		Substrate (By similarity)		Q
BINDING		22		22		Substrate (By similarity)		R
BINDING		39		39		Substrate (By similarity)		S
BINDING		42		42		Substrate (By similarity)		N
BINDING		71		71		Substrate (By similarity)		K
BINDING		299		299		Substrate (By similarity)		H
BINDING		419		419		FAD; via carbonyl oxygen (By similarity)		Y
BINDING		427		427		Substrate (By similarity)		K

Size range:	438-440 amino acids
Related UniRules:	None
Template:	O52582 (CDR_STAA8)
Scope:	Bacteria; Staphylococcus
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None