Accession	MF_01517
Dates	27-MAY-2004 (Created) 4-DEC-2008 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_01517; [distribution of match scores in UniProtKB];[seed alignment for MF_01517]

Identifier

MDH

Protein name

RecName: Full=Malate dehydrogenase; EC=1.1.1.37;

Gene name

mdh

FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity).

CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.

Pfam	PF02866; Ldh_1_C; 1; PF00056; Ldh_1_N; 1;
TIGRFAMs	TIGR01756; LDH_protist; 1; TIGR01757; Malate-DH_plant; 1; TIGR01759; MalateDH-SF1; 1; TIGR01758; MDH_euk_cyt; 1;
PROSITE	PS00068; MDH; 1;

Oxidoreductase, Tricarboxylic acid cycle, NAD.

GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

From: MDH_THETH (P10584)
Key		From		To		Description		Condition		FTGroup
NP_BIND		11		17		NAD (By similarity)		G-[AG]-x-G-x-[IV]-[GACS]
NP_BIND		129		131		NAD (By similarity)		[VT]-G-N
ACT_SITE		187		187		Proton acceptor (By similarity)		H
BINDING		92		92		Substrate (By similarity)		R
BINDING		98		98		Substrate (By similarity)		R
BINDING		105		105		NAD (By similarity)		N
BINDING		112		112		NAD (By similarity)		Q
BINDING		131		131		Substrate (By similarity)		N
BINDING		162		162		Substrate (By similarity)		R

Size range:	323-335 amino acids
Related UniRules:	MF_00487 (MDH); MF_00488 (LDH); MF_01516 (MDH)
Template:	P10584 (MDH_THETH)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BURTA, BURVG, RHOFD
Plasmid encoded:	None