Accession	MF_01511
Dates	17-FEB-2004 (Created) 7-JUN-2008 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_01511; [distribution of match scores in UniProtKB];[seed alignment for MF_01511]

Identifier

GUAC

Protein name

RecName: Full=GMP reductase; EC=1.7.1.7; AltName: Full=Guanosine 5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase;

Gene name

guaC

FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).

CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.

SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Pfam	PF00478; IMPDH; 1;
TIGRFAMs	TIGR01306; GMP_reduct_2; 1;
PROSITE	PS00487; IMP_DH_GMP_RED; 1;

Oxidoreductase, NADP.

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

From: GUAC_BACSU (O05269)
Key		From		To		Description		Condition		FTGroup
NP_BIND		204		227		NADP (Potential)
ACT_SITE		175		175		Thioimidate intermediate (By similarity)		C

Size range:	316-330 amino acids
Related UniRules:	None
Template:	O05269 (GUAC_BACSU)
Scope:	Bacteria; Firmicutes Bacteria; Betaproteobacteria Bacteria; Campylobacterales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None