HAMAP family: MF

Accession	MF_01417
Dates	5-MAR-2004 (Created) 4-MAY-2009 (Last updated, Version 16)

Data class

Protein

Predictors

Identifier

SPEA

Protein name

RecName:

Full=Biosynthetic arginine decarboxylase;
Short=ADC;
EC=4.1.1.19;

Gene name

speA

FUNCTION: Catalyzes the biosynthesis of agmatine from arginine (By similarity).

CATALYTIC ACTIVITY: L-arginine = agmatine + CO(2).

COFACTOR: Magnesium (By similarity).

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: Amino-acid degradation; L-arginine degradation via ADC pathway; agmatine from L-arginine: step 1/1.

SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Pfam	PF02784; Orn_Arg_deC_N; 1; PF00278; Orn_DAP_Arg_deC; 1;
PRINTS	PR01179; ODADCRBXLASE; 1;
TIGRFAMs	TIGR01273; speA; 1;
PROSITE	PS00878; ODR_DC_2_1; 1; PS00879; ODR_DC_2_2; 1;

Polyamine biosynthesis, Spermidine biosynthesis.

case <OC:Enterobacteriales> or <OC:Neisseriales>

Putrescine biosynthesis.

end case

Lyase, Decarboxylase, Pyridoxal phosphate, Metal-binding, Magnesium.

GO:0008792; Molecular function: arginine decarboxylase activity.

case <OC:Enterobacteriales> or <OC:Neisseriales>

GO:0009446; Biological process: putrescine biosynthetic process.

end case

GO:0008295; Biological process: spermidine biosynthetic process.

`From: SPEA_ECOLI (P21170)`
`Key`	`From`	`To`	`Description`	`Condition`	`FTGroup`
`REGION`	`307`	`317`	`Substrate-binding (Potential)`	`[FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF]`
`MOD_RES`	`127`	`127`	`N6-(pyridoxal phosphate)lysine (By similarity)`	`K`