Accession	MF_01384
Dates	8-MAY-2008 (Created) 4-JUL-2008 (Last updated, Version 6)

Data class

Protein

Predictors

HAMAP; MF_01384; [distribution of match scores in UniProtKB];[seed alignment for MF_01384]

Identifier

URED

Protein name

RecName: Full=Urease accessory protein ureD;

Gene name

ureD

Identifier

UREH

Protein name

RecName: Full=Urease accessory protein ureH;

Gene name

ureH

FUNCTION: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity).

SUBUNIT: UreD, ureF and ureG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of ureC. The ureE protein probably delivers the nickel (By similarity).

SUBUNIT: UreH, ureF and ureG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of ureC. The ureE protein probably delivers the nickel (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the ureD family.

Pfam	PF01774; UreD; 1;

Chaperone, Cytoplasm, Nickel insertion.

GO:0016151; Molecular function: nickel ion binding.
GO:0005737; Cellular component: cytoplasm.

Size range:	240-329 amino acids
Related UniRules:	None
Template:	Q09063 (URED_KLEAE); P17089 (URED_PROMI); Q9ZFR5 (URED_YERPE): [Recover all]
Scope:	Bacteria; Actinobacteria Bacteria; Bacteroidetes Bacteria; Chloroflexi Bacteria; Cyanobacteria Bacteria; Deinococcus-Thermus Bacteria; Firmicutes Bacteria; Proteobacteria Bacteria; Magnetococcus Bacteria; Verrucomicrobia Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BRASB, BRASO, BRUAB, BRUA2, BRUC2, BRUME, BRUO2, BRUSU, METEP, METPB, METRJ, OCHA4, PSESM, PSEU2, PSYCK, SACEN, STRGG, SYNJA
Plasmid encoded:	in ECOLX, HALMA, METRJ
Comments:	Called ureH in Helicobacter where ureD is an unrelated protein of the urease operon. Some E.coli EHEC strains are urease negative despite the presence of the operon in their genomes; in a few cases this has been shown to be due to nonsense mutations in ureD, for example ECO57. YERPE has a different nonsense mutation and is also non-functional. For some orally acquired pathogens (Brucella, Helicobacter, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons.