Accession	MF_01322
Dates	6-JAN-2004 (Created) 13-OCT-2008 (Last updated, Version 14)

Data class

Protein

Predictors

HAMAP; MF_01322; [distribution of match scores in UniProtKB];[seed alignment for MF_01322]

Identifier

RPOC

Protein name

RecName: Full=DNA-directed RNA polymerase subunit beta'; Short=RNAP subunit beta'; EC=2.7.7.6; AltName: Full=Transcriptase subunit beta'; AltName: Full=RNA polymerase subunit beta';

Gene name

rpoC

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).

CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).

SIMILARITY: Belongs to the RNA polymerase beta' chain family.

Pfam	PF04997; RNA_pol_Rpb1_1; 1; PF00623; RNA_pol_Rpb1_2; 1; PF04983; RNA_pol_Rpb1_3; 1; PF05000; RNA_pol_Rpb1_4; 1; PF04998; RNA_pol_Rpb1_5; 1;

Acetylation.

Transcription, Transferase, Nucleotidyltransferase, DNA-directed RNA polymerase.

GO:0003677; Molecular function: DNA binding.
GO:0003899; Molecular function: DNA-directed RNA polymerase activity.
GO:0006351; Biological process: transcription, DNA-dependent.

From: RPOC_ECOLI (P0A8T7)
Key		From		To		Description		Condition		FTGroup
MOD_RES		983		983		N6-acetyllysine (By similarity)		K

Size range:	1135-1690 amino acids
Related UniRules:	MF_01323 (RPOC1); MF_01324 (RPOC2)
Template:	Q9KWU6 (RPOC_THEAQ)
Scope:	Bacteria; except Cyanobacteria
Fusion:	Nter: MF_01321 (rpoB), <Unknown>; Cter: None
Duplicate:	in RHOS1
Plasmid encoded:	None
Comments:	Fused with rpoB in Helicobacter species and least some Wolbachia, but not in other epsilon proteobateria. In Acholeplasmataceae there is an unknown N-terminal extension of about 110 amino acids. In cyanobacteria and chloroplasts this protein is split into two parts. The N-terminus is known as gamma in cyanobacteria and beta' in chloroplasts (MF_01323), while the C-terminus is known as beta' in cyanobacteria and beta'' in chloroplasts (MF_01324).