Accession	MF_01285
Dates	5-FEB-2008 (Created) 20-JAN-2009 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01285; [distribution of match scores in UniProtKB];[seed alignment for MF_01285]

Identifier

RIFK

Protein name

RecName: Full=Riboflavin kinase; Short=RFK; EC=2.7.1.161; AltName: Full=CTP:riboflavin 5'-phosphotransferase; AltName: Full=CTP-dependent riboflavin kinase; AltName: Full=Flavokinase;

Gene name

rfk

FUNCTION: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) (By similarity).

CATALYTIC ACTIVITY: CTP + riboflavin = CDP + FMN.

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.

SIMILARITY: Belongs to the archaeal riboflavin kinase family.

Pfam	PF01982; DUF120; 1;

FMN, Kinase, Magnesium, Metal-binding, Transferase, Nucleotide-binding.

GO:0000166; Molecular function: nucleotide binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0016301; Molecular function: kinase activity.
GO:0016773; Molecular function: phosphotransferase activity, alcohol group as acceptor.
GO:0009398; Biological process: FMN biosynthetic process.

From: RIFK_METJA (Q60365)
Key		From		To		Description		Condition		FTGroup
NP_BIND		14		19		CDP (By similarity)
NP_BIND		112		115		CDP (By similarity)
METAL		43		43		Magnesium (By similarity)		T
METAL		45		45		Magnesium (By similarity)		N
BINDING		99		99		FMN (By similarity)		[TS]
BINDING (Optional)		100		100		FMN (By similarity)		Y
BINDING		107		107		FMN (By similarity)		E

Size range:	122-159 amino acids
Related UniRules:	None
Template:	Q60365 (RIFK_METJA)
Scope:	Archaea
Fusion:	Nter: <Unknown>; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Many family members are N-terminally fused with a putative winged HTH DNA-binding domain, that has not been annotated because of bad score and truncation. Possible wrong start in SULAC. Longer N-terminus in SULSO and IGNH4.