Accession	MF_01201
Dates	6-FEB-2002 (Created) 4-MAY-2009 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_01201; [distribution of match scores in UniProtKB];[seed alignment for MF_01201]

Identifier

ALR

Protein name

RecName: Full=Alanine racemase; EC=5.1.1.1;

Gene name

alr

FUNCTION: Provides the D-alanine required for cell wall biosynthesis (By similarity).

CATALYTIC ACTIVITY: L-alanine = D-alanine.

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.

PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

SIMILARITY: Belongs to the alanine racemase family.

Pfam	PF00842; Ala_racemase; 1;
PRINTS	PR00992; ALARACEMASE; 1;
TIGRFAMs	TIGR00492; alr; 1;
PROSITE	PS00395; ALANINE_RACEMASE; 1;

Cell shape, Cell wall biogenesis/degradation, Isomerase, Peptidoglycan synthesis, Pyridoxal phosphate.

GO:0008784; Molecular function: alanine racemase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006522; Biological process: alanine metabolic process.
GO:0009252; Biological process: peptidoglycan biosynthetic process.

From: ALR_BACST (P10724)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		39		39		Proton acceptor; specific for D-alanine (By similarity)		K
ACT_SITE		265		265		Proton acceptor; specific for L-alanine (By similarity)		Y
MOD_RES		39		39		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	328-397 amino acids
Related UniRules:	None
Template:	P10724 (ALR_BACST); Q9RER4 (ALR_AQUPY); Q9S5V6 (ALR_BACPS); P10725 (ALR1_BACSU); P0A6B4 (ALR1_ECOLI); P29012 (ALR2_ECOLI); O30746 (ALR2_KLEAE); Q9FCV2 (ALR_LACRE); O85045 (ALR_LISMO); Q9L888 (ALR_MYCAV); P94967 (ALR_MYCSM); P0A4X2 (ALR_MYCTU); Q9HUN4 (ALR1_PSEAE); Q9HTQ2 (ALR2_PSEAE); P33162 (ALR_PSEFL); Q9RAE7 (ALR2_RHIL3); P0A1A3 (ALR1_SALTY); P06191 (ALR2_SALTY); Q932V0 (ALR1_SHIDY); Q93HP9 (ALR1_SHISO): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in AGRT5, BACSU, CLOAB, ECO57, ECOLI, OCEIH, PSEAE, RHILO, SALTI, SALTY, STAAM, STAAN, STAAU, VIBCH, YERPE
Plasmid encoded:	in RHILO
Comments:	RPE1 type insert in RICPR; sequence not shown in alignment and not taken into account in size range. It is not possible to automatically make a distinction between alr and dadX (or dadB) genes, but if these two genes are retrived in a genome, note that the catabolic alanine racemase dadX (which only exists in several species) has to make part of the dad operon (i.e. must be close to dadA gene).