Accession	MF_01169
Dates	17-DEC-2005 (Created) 7-JUN-2008 (Last updated, Version 4)

Data class

Protein

Predictors

HAMAP; MF_01169; [distribution of match scores in UniProtKB];[seed alignment for MF_01169]

Identifier

ODO1

Protein name

RecName: Full=2-oxoglutarate dehydrogenase E1 component; EC=1.2.4.2; AltName: Full=Alpha-ketoglutarate dehydrogenase;

Gene name

odhA

Gene name

sucA, odhA

FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).

COFACTOR: Thiamine pyrophosphate (By similarity).

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Pfam	PF00676; E1_dh; 1; PF02779; Transket_pyr; 1;
TIGRFAMs	TIGR00239; 2oxo_dh_E1; 1;

Glycolysis, Oxidoreductase, Thiamine pyrophosphate.

GO:0004591; Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity.
GO:0030976; Molecular function: thiamin pyrophosphate binding.
GO:0006096; Biological process: glycolysis.

Size range:	910-1004 amino acids
Related UniRules:	None
Template:	P23129 (ODO1_BACSU)
Scope:	Bacteria; Bacillales Bacteria; Brucellaceae Bacteria; Leptospiraceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	This family is restricted taxonomically to some bacteria so as to avoid overlap with proteins that have similarity to alpha-ketoglutarate dehydrogenase but may be a different enzyme.