Accession	MF_01109
Dates	11-JUL-2003 (Created) 30-JUN-2008 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_01109; [distribution of match scores in UniProtKB];[seed alignment for MF_01109]

Identifier

OTC

Protein name

RecName: Full=Ornithine carbamoyltransferase; Short=OTCase; EC=2.1.3.3;

Identifier

OTCC

Protein name

RecName: Full=Ornithine carbamoyltransferase, catabolic; Short=OTCase; EC=2.1.3.3;

Gene name

argI

Gene name

argF

Gene name

arcB

CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.

PATHWAY: Amino-acid degradation; L-arginine degradation via ADI pathway; CO(2) and NH(3) from L-arginine: step 2/3.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the ATCase/OTCase family.

Pfam	PF00185; OTCace; 1; PF02729; OTCace_N; 1;
PRINTS	PR00100; AOTCASE; 1;
TIGRFAMs	TIGR00658; orni_carb_tr; 1;
PROSITE	PS00097; CARBAMOYLTRANSFERASE; 1;

Amino-acid biosynthesis, Arginine biosynthesis.

Arginine metabolism.

Cytoplasm, Transferase.

GO:0004585; Molecular function: ornithine carbamoyltransferase activity.

GO:0006526; Biological process: arginine biosynthetic process.

GO:0019546; Biological process: arginine deiminase pathway.

GO:0005737; Cellular component: cytoplasm.

From: OTCC_PSEAE (P08308)
Key		From		To		Description		Condition		FTGroup
REGION		57		61		Carbamoyl phosphate binding (By similarity)		S-T-R-T-R
REGION		273		276		Ornithine binding (By similarity)		H-C-L-P
BINDING		108		108		Carbamoyl phosphate (By similarity)		R
BINDING		135		135		Carbamoyl phosphate (By similarity)		H
SITE (Optional)		32		32		Important for structural integrity (By similarity)		K
SITE (Optional)		148		148		Important for structural integrity (By similarity)		E

Size range:	295-354 amino acids
Related UniRules:	None
Template:	P04391 (OTC1_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in ECOL6, LACLA, LISMO, PSEAE, PSEPK, RHIME, SALTI, SALTY, STAAM, STAAN, STAAW, STAES, STRA3, STRA5, STRMU
Plasmid encoded:	in HALSA, RHIME
Comments:	OTCases can be involved in the biosynthesis of arginine and in its catabolism, by the arginine deiminase pathway. Some bacteria possess two distinct OTCases; some do not degrade arginine using this pathway and others do not synthesize arginine. As it is impossible to distinguish between anabolic and catabolic OTCases based on sequence similarity alone, if paralogs are found in a given genome, then one is probably the anabolic enzyme and the other the catabolic one, named arcB, which is usually located in the arcABC operon. E.coli K-12 carries two genes for anabolic OTCase, argF and argI; their products interact to form a family of four trimeric isoenzymes. Only argI can be found in E.coli B, E.coli W or in other enterobacteria.