Accession	MF_01107
Dates	11-FEB-2003 (Created) 4-MAY-2009 (Last updated, Version 35)

Data class

Protein

Predictors

HAMAP; MF_01107; [distribution of match scores in UniProtKB];[seed alignment for MF_01107]

Identifier

ARGD

Protein name

RecName: Full=Acetylornithine/succinyldiaminopimelate aminotransferase; Short=ACOAT; Short=Succinyldiaminopimelate transferase; Short=DapATase; EC=2.6.1.11; EC=2.6.1.17;

Gene name

argD, dapC

Protein name

RecName: Full=Acetylornithine/acetyl-lysine aminotransferase; Short=ACOAT; EC=2.6.1.11; EC=2.6.1.-;

Gene name

argD, lysJ

Protein name

RecName: Full=Acetylornithine aminotransferase; Short=ACOAT; EC=2.6.1.11;

Gene name

argD

FUNCTION: Involved in both the arginine and lysine biosynthetic pathways (By similarity).

CATALYTIC ACTIVITY: N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.

CATALYTIC ACTIVITY: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate.

CATALYTIC ACTIVITY: N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.

CATALYTIC ACTIVITY: N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.

CATALYTIC ACTIVITY: N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.

COFACTOR: Binds 1 pyridoxal phosphate per subunit (By similarity).

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-diaminopimelate from tetrahydrodipicolinate (succinylase route): step 2/3.

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

MISCELLANEOUS: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Pfam	PF00202; aminotran_3; 1;
TIGRFAMs	TIGR00707; argD; 1;
PROSITE	PS00600; AA_TRANSFER_CLASS_3; 1;

Cytoplasm, Amino-acid biosynthesis, Arginine biosynthesis.

Lysine biosynthesis.

Transferase, Aminotransferase, Pyridoxal phosphate.

GO:0003992; Molecular function: acetylornithine transaminase activity.

GO:0009016; Molecular function: succinyldiaminopimelate transaminase activity.

GO:0006526; Biological process: arginine biosynthetic process.

GO:0009085; Biological process: lysine biosynthetic process.

GO:0005737; Cellular component: cytoplasm.

From: ARGD_THET8 (Q5SHH5)
Key		From		To		Description		Condition		FTGroup
REGION (Optional)		113		114		Pyridoxal phosphate binding (By similarity)		G-T
REGION		225		228		Pyridoxal phosphate binding (By similarity)		D-E-[IV]-Q
BINDING		140		140		Pyridoxal phosphate; via carbonyl oxygen (By similarity)		F
BINDING		143		143		N(2)-acetyl-L-ornithine (By similarity)		R
BINDING		282		282		N(2)-acetyl-L-ornithine (By similarity)		[ST]
BINDING		283		283		Pyridoxal phosphate (By similarity)		T
MOD_RES		254		254		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	362-431 amino acids
Related UniRules:	MF_01689 (OAT (supersedes the current rule)); MF_01173 (ASTC (supersedes the current rule))
Template:	P18335 (ARGD_ECOLI); Q93R93 (ARGD_THET2); Q7SI94 (ARGD_SULSO): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BORBR, BORPA, BORPE, BRAJA, PSESM
Plasmid encoded:	None