Accession	MF_01091
Dates	27-NOV-2003 (Created) 7-JUN-2008 (Last updated, Version 15)

Data class

Protein

Predictors

HAMAP; MF_01091; [distribution of match scores in UniProtKB];[seed alignment for MF_01091]

Identifier

MER

Protein name

RecName: Full=5,10-methylenetetrahydromethanopterin reductase; EC=1.5.99.11; AltName: Full=Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase; AltName: Full=Methylene-H(4)MPT reductase;

Gene name

mer

FUNCTION: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT (By similarity).

FUNCTION: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT (By similarity).

CATALYTIC ACTIVITY: 5-methyltetrahydromethanopterin + coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420.

PATHWAY: One-carbon metabolism; methanogenesis from carbone dioxide; methyl-CoM from 5,10-methylene-H(4)MPT: step 1/2.

PATHWAY: Metabolic intermediate metabolism; lactic acid oxidation.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the mer family.

Pfam	PF00296; bac_luciferase; 1;

Cytoplasm, Methanogenesis.

Cytoplasm, One-carbon metabolism, Oxidoreductase.

GO:0018537; Molecular function: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity.
GO:0006730; Biological process: one-carbon compound metabolic process.

GO:0015948; Biological process: methanogenesis.

GO:0005737; Cellular component: cytoplasm.

Size range:	321-349 amino acids
Related UniRules:	None
Template:	Q8TXY4 (MER_METKA); O27784 (MER_METTH); Q50744 (MER_METTM): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None