| Accession |
MF_01019 |
| Dates |
28-MAY-2002 (Created)
23-MAR-2009 (Last updated, Version 25) |
| Protein name |
| RecName: |
Full=Histidine biosynthesis bifunctional protein hisIE; |
| RecName: |
Full=Phosphoribosyl-AMP cyclohydrolase;
Short=PRA-CH;
EC=3.5.4.19; |
| RecName: |
Full=Phosphoribosyl-ATP pyrophosphatase;
Short=PRA-PH;
EC=3.6.1.31; |
|
CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-AMP + diphosphate.
CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: In the N-terminal section; belongs to the PRA-CH family.
SIMILARITY: In the C-terminal section; belongs to the PRA-PH family.
GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
| From: HIS2_ECOLI (P06989) |
| Key |
|
From |
|
To |
|
Description |
|
Condition |
|
FTGroup |
| REGION |
|
Nter |
|
114 |
|
Phosphoribosyl-AMP cyclohydrolase |
|
|
|
|
| REGION |
|
115 |
|
Cter |
|
Phosphoribosyl-ATP pyrophosphohydrolase |
|
|
|
|
| Size range: |
197-231 amino acids |
| Related UniRules: |
MF_01020 (HIS2); MF_01021 (HIS3) |
| Template: |
P06989 (HIS2_ECOLI) |
| Scope: |
Bacteria
Archaea |
| Fusion: |
Nter: None; Cter: None |
| Duplicate: |
None |
| Plasmid encoded: |
None |
| Comments: |
See MF_01020 and MF_01021 for the entries relevant to hisI and hisE |
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