Accession	MF_00747
Dates	6-JAN-2004 (Created) 7-JUN-2008 (Last updated, Version 18)

Data class

Protein

Predictors

HAMAP; MF_00747; [distribution of match scores in UniProtKB];[seed alignment for MF_00747]

Identifier

ACEK

Protein name

RecName: Full=Isocitrate dehydrogenase kinase/phosphatase; Short=IDH kinase/phosphatase; Short=IDHK/P; EC=2.7.11.5; EC=3.1.3.-;

Gene name

aceK

FUNCTION: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity).

CATALYTIC ACTIVITY: ATP + [isocitrate dehydrogenase (NADP(+))] = ADP + [isocitrate dehydrogenase (NADP(+))] phosphate.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the aceK family.

Pfam	PF06315; AceK; 1;

Cytoplasm, ATP-binding, Glyoxylate bypass, Hydrolase, Kinase, Multifunctional enzyme, Nucleotide-binding, Protein phosphatase, Transferase, Tricarboxylic acid cycle.

GO:0005524; Molecular function: ATP binding.
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds.
GO:0008772; Molecular function: [isocitrate dehydrogenase (NADP+)] kinase activity.
GO:0006097; Biological process: glyoxylate cycle.
GO:0006099; Biological process: tricarboxylic acid cycle.
GO:0005737; Cellular component: cytoplasm.

From: ACEK_ECOLI (P11071)
Key		From		To		Description		Condition		FTGroup
NP_BIND		315		321		ATP (By similarity)		A-x-G-x-x-G-[LIVMT]
ACT_SITE		371		371		By similarity		D
BINDING		336		336		ATP (By similarity)		K

Size range:	564-625 amino acids
Related UniRules:	None
Template:	P11071 (ACEK_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEHT
Plasmid encoded:	None