Accession	MF_00741
Dates	27-NOV-2003 (Created) 23-MAR-2009 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00741_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00741_B]

Predictors

HAMAP; MF_00741_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00741_A]

Identifier

PUR5

Protein name

RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase; EC=6.3.3.1; AltName: Full=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase; AltName: Full=AIR synthase;

Gene name

purM

CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the AIR synthase family.

Pfam	PF00586; AIRS; 1; PF02769; AIRS_C; 1;
TIGRFAMs	TIGR00878; purM; 1; TIGR01847; bacteriocin_sig; 1;

ATP-binding, Cytoplasm, Ligase, Nucleotide-binding, Purine biosynthesis.

GO:0004641; Molecular function: phosphoribosylformylglycinamidine cyclo-ligase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:

331-388 amino acids

Size range:

319-350 amino acids

Related UniRules:	None
Template:	P08178 (PUR5_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None