Accession	MF_00733
Dates	24-NOV-2003 (Created) 7-JUN-2008 (Last updated, Version 12)

Data class

Protein

Predictors

HAMAP; MF_00733; [distribution of match scores in UniProtKB];[seed alignment for MF_00733]

Identifier

ROCA

Protein name

RecName: Full=1-pyrroline-5-carboxylate dehydrogenase; Short=P5C dehydrogenase; EC=1.5.1.12;

Gene name

rocA

CATALYTIC ACTIVITY: (S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.

PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.

SIMILARITY: Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Pfam	PF00171; aldedh; 1;
TIGRFAMs	TIGR01237; D1pyr5carbox2; 1; TIGR01804; BADH; 1; TIGR01780; SSADH; 1;
PROSITE	PS00070; ALDEHYDE_DEHYDR_CYS; 1; PS00687; ALDEHYDE_DEHYDR_GLU; 1;

Oxidoreductase, NAD.

GO:0003842; Molecular function: 1-pyrroline-5-carboxylate dehydrogenase activity.
GO:0006537; Biological process: glutamate biosynthetic process.

From: ROCA_BACSU (P39634)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		286		286		By similarity		E
ACT_SITE		320		320		By similarity		C

Size range:	514-515 amino acids
Related UniRules:	None
Template:	P39634 (ROCA_BACSU)
Scope:	Bacteria; Bacillales
Fusion:	Nter: None; Cter: None
Duplicate:	in BACHD, BACSU
Plasmid encoded:	None