Accession	MF_00627
Dates	24-MAR-2003 (Created) 4-DEC-2008 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_00627; [distribution of match scores in UniProtKB];[seed alignment for MF_00627]

Identifier

TDH

Protein name

RecName: Full=L-threonine 3-dehydrogenase; EC=1.1.1.103;

Protein name

RecName: Full=Probable L-threonine 3-dehydrogenase; EC=1.1.1.103;

Gene name

tdh

CATALYTIC ACTIVITY: L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH.

COFACTOR: Binds 2 zinc ions per subunit (By similarity).

PATHWAY: Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.

Pfam	PF00107; adh_zinc; 1; PF00107; ADH_zinc_N; 1;
TIGRFAMs	TIGR00692; tdh; 1;
PROSITE	PS00059; ADH_ZINC; 1;

Cytoplasm, Oxidoreductase.

Zinc, Metal-binding.

NAD.

GO:0008743; Molecular function: L-threonine 3-dehydrogenase activity.

GO:0008270; Molecular function: zinc ion binding.

GO:0006567; Biological process: threonine catabolic process.
GO:0005737; Cellular component: cytoplasm.

From: TDH_ECOLI (P07913)
Key		From		To		Description		Condition		FTGroup
METAL		38		38		Zinc 1; catalytic (By similarity)		C		1
METAL		63		63		Zinc 1; catalytic (By similarity)		H		1
METAL		93		93		Zinc 2 (By similarity)		C		2
METAL		96		96		Zinc 2 (By similarity)		C		2
METAL		99		99		Zinc 2 (By similarity)		C		2
METAL		107		107		Zinc 2 (By similarity)		C		2
METAL		148		148		Zinc 1; catalytic (By similarity)		[DE]		1

Size range:	340-361 amino acids
Related UniRules:	None
Template:	P07913 (TDH_ECOLI)
Scope:	Bacteria Archaea Archaea; Thermococcales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None