Accession	MF_00607
Dates	9-DEC-2002 (Created) 7-JUN-2008 (Last updated, Version 14)

Data class

Protein

Predictors

HAMAP; MF_00607; [distribution of match scores in UniProtKB];[seed alignment for MF_00607]

Identifier

KSGA

Protein name

RecName: Full=Dimethyladenosine transferase; EC=2.1.1.-; AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase; AltName: Full=16S rRNA dimethylase; AltName: Full=High level kasugamycin resistance protein ksgA; AltName: Full=Kasugamycin dimethyltransferase;

Protein name

RecName: Full=Probable dimethyladenosine transferase; EC=2.1.1.-; AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; AltName: Full=16S rRNA dimethylase;

Gene name

ksgA

FUNCTION: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance (By similarity).

FUNCTION: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle (By similarity).

SIMILARITY: Belongs to the rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

Pfam	PF00398; RrnaAD; 1;
TIGRFAMs	TIGR00755; ksgA; 1;
PROSITE	PS01131; RRNA_A_DIMETH; 1;

RNA-binding, rRNA processing, S-adenosyl-L-methionine, Transferase, Methyltransferase.

Antibiotic resistance.

GO:0016433; Molecular function: rRNA (adenine) methyltransferase activity.
GO:0046677; Biological process: response to antibiotic.
GO:0000154; Biological process: rRNA modification.

From: KSGA_ECOLI (P06992)
Key		From		To		Description		Condition		FTGroup
BINDING (Optional)		18		18		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		[NH]
BINDING		20		20		S-adenosyl-L-methionine; via amide nitrogen (By similarity)		[ILVM]
BINDING		45		45		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		G
BINDING		66		66		S-adenosyl-L-methionine (By similarity)		E
BINDING		91		91		S-adenosyl-L-methionine (By similarity)		D
BINDING		113		113		S-adenosyl-L-methionine (By similarity)		N

Size range:	228-330 amino acids
Related UniRules:	None
Template:	P06992 (KSGA_ECOLI); P13956 (ERM_BACSU): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None