Accession	MF_00605
Dates	29-NOV-2002 (Created) 7-JUN-2008 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_00605; [distribution of match scores in UniProtKB];[seed alignment for MF_00605]

Identifier

TRMD

Protein name

RecName: Full=tRNA (guanine-N(1)-)-methyltransferase; EC=2.1.1.31; AltName: Full=M1G-methyltransferase; AltName: Full=tRNA [GM37] methyltransferase;

Gene name

trmD

FUNCTION: Specifically methylates guanosine-37 in various tRNAs (By similarity).

CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the RNA methyltransferase trmD family.

Pfam	PF01746; tRNA_m1G_MT; 1;
TIGRFAMs	TIGR00088; trmD; 1;

Cytoplasm, Methyltransferase, Transferase, tRNA processing, S-adenosyl-L-methionine.

GO:0009019; Molecular function: tRNA (guanine-N1-)-methyltransferase activity.
GO:0006400; Biological process: tRNA modification.
GO:0005737; Cellular component: cytoplasm.

From: TRMD_ECOLI (P0A873)
Key		From		To		Description		Condition		FTGroup
REGION		133		138		S-adenosyl-L-methionine binding (By similarity)		[ILVM]-G-[DN]-[YF]-[IV]-[ILVM]
BINDING		113		113		S-adenosyl-L-methionine; via amide nitrogen (By similarity)		G

Size range:	222-361 amino acids
Related UniRules:	None
Template:	P0A873 (TRMD_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: <Unknown>
Duplicate:	None
Plasmid encoded:	None