Accession	MF_00559
Dates	25-MAY-2002 (Created) 7-JUN-2008 (Last updated, Version 18)

Data class

Protein

Predictors

HAMAP; MF_00559; [distribution of match scores in UniProtKB];[seed alignment for MF_00559]

Identifier

G3P

Protein name

RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase; Short=GAPDH; EC=1.2.1.59; AltName: Full=NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase;

Gene name

gap

CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)(+) = 3-phospho-D-glyceroyl phosphate + NAD(P)H.

PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

PROSITE	PS00071; GAPDH; 1;
Pfam	PF02800; Gp_dh_C; 1; PF00044; Gp_dh_N; 1;
TIGRFAMs	TIGR01546; GAPDH-II_archae; 1;

Cytoplasm, Glycolysis, NAD, NADP, Oxidoreductase.

GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity.
GO:0006096; Biological process: glycolysis.
GO:0005737; Cellular component: cytoplasm.

From: G3P_PYRHO (O59494)
Key		From		To		Description		Condition		FTGroup
NP_BIND		12		13		NAD (By similarity)		[TS]-[IV]
REGION		140		142		Glyceraldehyde 3-phosphate binding (By similarity)		S-C-N
REGION		192		193		Glyceraldehyde 3-phosphate binding (By similarity)		H-[AG]
ACT_SITE		141		141		Nucleophile (By similarity)		C
BINDING		111		111		NAD; via amide nitrogen (By similarity)		G
BINDING		167		167		NAD (By similarity)		R
BINDING		298		298		NAD; via carbonyl oxygen (By similarity)		Q

Size range:	334-354 amino acids
Related UniRules:	None
Template:	P10618 (G3P_METFE); P39460 (G3P_SULSO); O59494 (G3P_PYRHO): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in METAC, METBF
Plasmid encoded:	None