Accession	MF_00487
Dates	22-NOV-2001 (Created) 4-DEC-2008 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00487; [distribution of match scores in UniProtKB];[seed alignment for MF_00487]

Identifier

MDH

Protein name

RecName: Full=Malate dehydrogenase; EC=1.1.1.37;

Gene name

mdh

FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity).

CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.

SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 3 family.

Pfam	PF02866; Ldh_1_C; 1; PF00056; Ldh_1_N; 1;
PRINTS	PR00086; LLDHDRGNASE; 1;
TIGRFAMs	TIGR01771; L-LDH-NAD; 1; TIGR01763; MalateDH_bact; 1;

NAD, Oxidoreductase, Tricarboxylic acid cycle.

Phosphoprotein.

GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

From: MDH_HALMA (Q07841)
Key		From		To		Description		Condition		FTGroup
NP_BIND		8		14		NAD (By similarity)		G-x(1,2)-G-x-x-G
NP_BIND		119		121		NAD (By similarity)		[VILT]-[GSNAT]-N
ACT_SITE		176		176		Proton acceptor (By similarity)		H
BINDING (Optional)		34		34		NAD (By similarity)		D
BINDING		83		83		Substrate (By similarity)		R
BINDING		89		89		Substrate (By similarity)		R
BINDING		96		96		NAD (By similarity)		N
BINDING		121		121		Substrate (By similarity)		N
BINDING		152		152		Substrate (By similarity)		R

From: MDH_BACSU (P49814)
Key		From		To		Description		Condition		FTGroup
MOD_RES		149		149		Phosphoserine (By similarity)		S

Size range:	278-335 amino acids
Related UniRules:	MF_00488 (LDH (supersedes the current rule)); MF_01516 (MDH); MF_01517 (MDH)
Template:	P80040 (MDH_CHLAA); P80039 (MDH_CHLTE); O08349 (MDH_ARCFU); Q07841 (MDH_HALMA); Q60176 (MDH_METJA); P61889 (MDH_ECOLI): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in ANADE, AQUAE, RHOPB
Plasmid encoded:	None
Comments:	Also called LDH-like MDH