Accession	MF_00387
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00387; [distribution of match scores in UniProtKB];[seed alignment for MF_00387]

Identifier

LPXA

Protein name

RecName: Full=Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Short=UDP-N-acetylglucosamine acyltransferase; EC=2.3.1.129;

Gene name

lpxA

FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).

FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane (Potential).

CATALYTIC ACTIVITY: (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.

PATHWAY: Glycolipid biosynthesis; lipid (IV)A biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-D-glucosamine: step 1/6.

SUBUNIT: Homotrimer (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Pfam	PF00132; hexapep; 1;
PROSITE	PS00101; HEXAPEP_TRANSFERASES; 1;

Cytoplasm.

Transferase, Acyltransferase, Lipid A biosynthesis, Lipid synthesis, Repeat.

GO:0008780; Molecular function: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

GO:0009507; Cellular component: chloroplast.

GO:0005737; Cellular component: cytoplasm.

Size range:	257-283 amino acids
Related UniRules:	MF_00523 (LPXD)
Template:	P0A722 (LPXA_ECOLI); P32199 (LPXA_RICRI): [Recover all]
Scope:	Bacteria Plastid
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None