Accession	MF_00334
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00334; [distribution of match scores in UniProtKB];[seed alignment for MF_00334]

Identifier

HGD

Protein name

RecName: Full=Homogentisate 1,2-dioxygenase; EC=1.13.11.5; AltName: Full=Homogentisicase; AltName: Full=Homogentisate oxygenase; AltName: Full=Homogentisic acid oxidase;

Gene name

hmgA

CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.

COFACTOR: Iron (By similarity).

PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.

SIMILARITY: Belongs to the homogentisate dioxygenase family.

Pfam	PF04209; HgmA; 1;
TIGRFAMs	TIGR01015; hmgA; 1;

Oxidoreductase, Dioxygenase.

Metal-binding, Iron.

Phenylalanine catabolism, Tyrosine catabolism.

GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity.
GO:0005506; Molecular function: iron ion binding.
GO:0006559; Biological process: L-phenylalanine catabolic process.
GO:0006572; Biological process: tyrosine catabolic process.

From: HGD_RHIME (Q9X4F5)
Key		From		To		Description		Condition		FTGroup
METAL		349		349		Iron (By similarity)		H		1
METAL		355		355		Iron (By similarity)		E		1
METAL		385		385		Iron (By similarity)		H		1

Size range:	416-458 amino acids
Related UniRules:	None
Template:	Q9X4F5 (HGD_RHIME)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in RALSO