Accession	MF_00324
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00324; [distribution of match scores in UniProtKB];[seed alignment for MF_00324]

Identifier

DP2L

Protein name

RecName: Full=DNA polymerase II large subunit; Short=Pol II; EC=2.7.7.7;

Gene name

polC

FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.

SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).

SIMILARITY: Belongs to the archaeal DNA polymerase II family.

Pfam	PF03833; PolC_DP2; 1;
TIGRFAMs	TIGR00354; polC; 1;

Transferase, Nucleotidyltransferase, DNA-directed DNA polymerase, DNA replication, Hydrolase, Nuclease, Exonuclease, DNA-binding, Multifunctional enzyme.

GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000738; Biological process: DNA catabolic process, exonucleolytic.
GO:0006261; Biological process: DNA-dependent DNA replication.

Size range:	1080-1270 amino acids
Related UniRules:	None
Template:	Q59024 (DP2L_METJA); P81409 (DP2L_PYRFU): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Inteins deleted in HALMA, HALWD, HALSA, METMJ, METHJ, PYRAB, PYRHO and PYRKO.