Accession	MF_00315
Dates	1-JUN-2001 (Created) 26-SEP-2008 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00315; [distribution of match scores in UniProtKB];[seed alignment for MF_00315]

Identifier

DXS

Protein name

RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase; EC=2.2.1.7; AltName: Full=1-deoxyxylulose-5-phosphate synthase; Short=DXP synthase; Short=DXPS;

Gene name

dxs

FUNCTION: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity).

CATALYTIC ACTIVITY: Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO(2).

COFACTOR: Binds 1 thiamine pyrophosphate per subunit (By similarity).

PATHWAY: Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the transketolase family. DXPS subfamily.

TIGRFAMs	TIGR00204; dxs; 1;
PROSITE	PS00801; TRANSKETOLASE_1; 1; PS00802; TRANSKETOLASE_2; 1;

Transferase, Thiamine pyrophosphate, Isoprene biosynthesis, Thiamine biosynthesis.

GO:0008661; Molecular function: 1-deoxy-D-xylulose-5-phosphate synthase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.
GO:0009228; Biological process: thiamin biosynthetic process.

Size range:	583-680 amino acids
Related UniRules:	None
Template:	P77488 (DXS_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in KITGR, STRAW, STRCO
Plasmid encoded:	None
Comments:	Atypical sequences in BUCAP and LISMO with internal deletions not taken into account in size range and alignment