| Accession |
MF_00252 |
| Dates |
1-JUN-2001 (Created)
25-SEP-2008 (Last updated, Version 26) |
| Protein name |
| RecName: |
Full=Lysyl-tRNA synthetase;
EC=6.1.1.6; |
| AltName: |
Full=Lysine--tRNA ligase;
Short=LysRS; |
|
CATALYTIC ACTIVITY: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
COFACTOR: Binds 3 magnesium ions per subunit (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
case <FT:4> or <FT:5>
end case
GO:0005524; Molecular function: ATP binding.
GO:0004824; Molecular function: lysine-tRNA ligase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006430; Biological process: lysyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
| From: SYK2_ECOLI (P0A8N5) |
| Key |
|
From |
|
To |
|
Description |
|
Condition |
|
FTGroup |
| METAL |
|
415 |
|
415 |
|
Magnesium 1 (By similarity) |
|
[ED] |
|
|
| METAL |
|
422 |
|
422 |
|
Magnesium 1 (By similarity) |
|
E |
|
|
| METAL |
|
422 |
|
422 |
|
Magnesium 2 (By similarity) |
|
E |
|
|
case <OC:Escherichia> or <OC:Shigella>
| Key |
|
From |
|
To |
|
Description |
|
Condition |
|
FTGroup |
| MOD_RES |
|
114 |
|
114 |
|
N6-acetyllysine (By similarity) |
|
K |
|
|
| MOD_RES |
|
156 |
|
156 |
|
N6-acetyllysine (By similarity) |
|
K |
|
|
end case
| Size range: |
485-597 amino acids |
| Related UniRules: |
None |
| Template: |
P0A8N3 (SYK1_ECOLI); P0A8N5 (SYK2_ECOLI): [Recover all] |
| Scope: |
Bacteria
Archaea |
| Fusion: |
Nter: <Unknown>; Cter: None |
| Duplicate: |
in ECOLI, ECOL6, ECO57, MYCPU, MYCTU |
| Plasmid encoded: |
None |
| Comments: |
Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both. Weird insertion in AQUAE. Unknown C-terminal domain in SYK2_MYCTU. |
View rule in raw text format (no links)
ExPASy Home page
