Accession	MF_00224
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00224_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00224_B]

Predictors

HAMAP; MF_00224_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00224_A]

Identifier

PYRD

Protein name

RecName: Full=Dihydroorotate dehydrogenase; EC=1.3.3.1; AltName: Full=Dihydroorotate oxidase; AltName: Full=DHOdehase; Short=DHODase; Short=DHOD;

Gene name

pyrD

CATALYTIC ACTIVITY: (S)-dihydroorotate + O(2) = orotate + H(2)O(2).

COFACTOR: Binds 1 FMN per subunit (By similarity).

PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6.

SUBUNIT: Heterotetramer of 2 pyrK and 2 pyrD subunits (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Pfam	PF01180; DHOdehase; 1;
TIGRFAMs	TIGR01036; pyrD_sub2; 1; TIGR01037; pyrD_sub1_fam; 1;
PROSITE	PS00911; DHODEHASE_1; 1; PS00912; DHODEHASE_2; 1;

Cytoplasm, Pyrimidine biosynthesis, Oxidoreductase, Flavoprotein, FMN.

GO:0004158; Molecular function: dihydroorotate oxidase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: PYRD_BACSU (P25996)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		128		128		Nucleophile (By similarity)		C

From: PYRD_ARCFU (O29513)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		128		128		Nucleophile (By similarity)		[SC]

Size range:

270-313 amino acids

Size range:

290-309 amino acids

Related UniRules:	MF_00225 (PYRD)
Template:	P25996 (PYRD_BACSU); Q53ZE5 (PYRDA_LACLC): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in ENTFA, LACLA, LACLM
Plasmid encoded:	None