Accession	MF_00222
Dates	1-JUN-2001 (Created) 26-SEP-2008 (Last updated, Version 28)

Data class

Protein

Predictors

HAMAP; MF_00222; [distribution of match scores in UniProtKB];[seed alignment for MF_00222]

Identifier

AROE

Protein name

RecName: Full=Shikimate dehydrogenase; EC=1.1.1.25;

Gene name

aroE

CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.

PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.

SIMILARITY: Belongs to the shikimate dehydrogenase family.

Pfam	PF01488; Shikimate_DH; 1; PF08501; Shikimate_dh_N; 1;
TIGRFAMs	TIGR00507; aroE; 1;

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, NADP, Oxidoreductase.

GO:0004764; Molecular function: shikimate 5-dehydrogenase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

From: AROE_HAEIN (P43876)
Key		From		To		Description		Condition		FTGroup
NP_BIND		126		130		NADP (By similarity)		G-[AGNSVY]-G-G-[AISV]
ACT_SITE		65		65		Proton acceptor (Potential)		K

Size range:	253-295 amino acids
Related UniRules:	MF_01578 (YDIB (supersedes the current rule))
Template:	P15770 (AROE_ECOLI); P43876 (AROE_HAEIN); Q58484 (AROE_METJA); P44774 (Y607_HAEIN); Q9X5C9 (AROE_CORGL): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: MF_00214 (aroD); Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Aroe in CORGL catalyzes the NAD(+)-dependent oxidation of both quinate and shikimate with a higher catalytic efficiency for quinate rather than shikimate, and seems to play a key role in the quinate-degradation pathway (PubMed=18566515).