Accession	MF_00219
Dates	1-JUN-2001 (Created) 24-JUL-2008 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00219; [distribution of match scores in UniProtKB];[seed alignment for MF_00219]

Identifier

PYRC

Protein name

RecName: Full=Dihydroorotase; Short=DHOase; EC=3.5.2.3;

Gene name

pyrC

CATALYTIC ACTIVITY: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.

COFACTOR: Binds 2 zinc ions per subunit (By similarity).

PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the DHOase family. Type 1 subfamily.

Pfam	PF00744; Dihydrooratase; 1;
TIGRFAMs	TIGR00856; pyrC_dimer; 1; TIGR00857; pyrC_multi; 1;
PROSITE	PS00482; DIHYDROOROTASE_1; 1; PS00483; DIHYDROOROTASE_2; 1;

Pyrimidine biosynthesis, Hydrolase, Metal-binding, Zinc.

GO:0004151; Molecular function: dihydroorotase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.

From: PYRC_ECOLI (P05020)
Key		From		To		Description		Condition		FTGroup
METAL		17		17		Zinc 1 (By similarity)		H
METAL		19		19		Zinc 1 (By similarity)		H
METAL		103		103		Zinc 1; via carbamate group (By similarity)		K
METAL		103		103		Zinc 2; via carbamate group (By similarity)		K
METAL		140		140		Zinc 2 (By similarity)		H
METAL		178		178		Zinc 2 (By similarity)		H
METAL		251		251		Zinc 1 (By similarity)		D
MOD_RES		103		103		N6-carboxylysine (By similarity)		K

Size range:	339-350 amino acids
Related UniRules:	MF_00220 (PYRC)
Template:	P05020 (PYRC_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None