Accession	MF_00218
Dates	1-JUN-2001 (Created) 5-MAY-2009 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00218; [distribution of match scores in UniProtKB];[seed alignment for MF_00218]

Identifier

DCUP

Protein name

RecName: Full=Uroporphyrinogen decarboxylase; Short=URO-D; Short=UPD; EC=4.1.1.37;

Gene name

hemE

FUNCTION: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity).

CATALYTIC ACTIVITY: Uroporphyrinogen III = coproporphyrinogen + 4 CO(2).

PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.

PROSITE	PS00906; UROD_1; 1; PS00907; UROD_2; 1;
Pfam	PF01208; URO-D; 1;
TIGRFAMs	TIGR01464; hemE; 1;

Cytoplasm, Lyase, Decarboxylase, Porphyrin biosynthesis.

GO:0004853; Molecular function: uroporphyrinogen decarboxylase activity.
GO:0006779; Biological process: porphyrin biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: DCUP_BACSU (P32395)
Key		From		To		Description		Condition		FTGroup
REGION		29		33		Substrate binding (By similarity)		R-x-[AVS]-x-R
BINDING (Optional)		48		48		Substrate (By similarity)		F
BINDING		78		78		Substrate (By similarity)		D
BINDING		154		154		Substrate (By similarity)		Y
BINDING		209		209		Substrate (By similarity)		[ST]
BINDING		322		322		Substrate (By similarity)		H
SITE		78		78		Transition state stabilizer (By similarity)		D

Size range:	324-385 amino acids
Related UniRules:	None
Template:	P32395 (DCUP_BACSU); P32920 (DCUP_RHOS4); P06132 (DCUP_HUMAN): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None