Accession	MF_00209
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00209; [distribution of match scores in UniProtKB];[seed alignment for MF_00209]

Identifier

IPYR

Protein name

RecName: Full=Inorganic pyrophosphatase; EC=3.6.1.1; AltName: Full=Pyrophosphate phospho-hydrolase; Short=PPase;

Gene name

ppa

CATALYTIC ACTIVITY: Diphosphate + H(2)O = 2 phosphate.

COFACTOR: Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the PPase family.

Pfam	PF00719; Pyrophosphatase; 1;
PROSITE	PS00387; PPASE; 1;

Cytoplasm, Hydrolase, Magnesium, Metal-binding.

GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.

From: IPYR_ECOLI (P0A7A9)
Key		From		To		Description		Condition		FTGroup
METAL		66		66		Magnesium 1 (By similarity)		D
METAL		71		71		Magnesium 1 (By similarity)		D
METAL		71		71		Magnesium 2 (By similarity)		D
METAL		103		103		Magnesium 1 (By similarity)		D

Size range:	158-215 amino acids
Related UniRules:	None
Template:	P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in PSESM
Plasmid encoded:	None