Accession	MF_00178
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00178; [distribution of match scores in UniProtKB];[seed alignment for MF_00178]

Identifier

RISB

Protein name

RecName: Full=6,7-dimethyl-8-ribityllumazine synthase; Short=DMRL synthase; Short=Lumazine synthase; EC=2.5.1.9; AltName: Full=Riboflavin synthase beta chain;

Gene name

ribH

FUNCTION: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine (By similarity).

CATALYTIC ACTIVITY: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 6,7-dimethyl-8-(1-D-ribityl)lumazine and riboflavin from 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine: step 1/1.

SIMILARITY: Belongs to the DMRL synthase family.

Pfam	PF00885; DMRL_synthase; 1;
TIGRFAMs	TIGR00114; ribH; 1;

Riboflavin biosynthesis, Transferase.

GO:0004746; Molecular function: riboflavin synthase activity.
GO:0009231; Biological process: riboflavin biosynthetic process.

Size range:	133-190 amino acids
Related UniRules:	None
Template:	P61714 (RISB_ECOLI); O66529 (RISB_AQUAE); P11998 (RISB_BACSU); P61711 (RISB2_BRUAB): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BRAJA, BRUME, BRUSU, CAUCR, PSESM, RHILO, RHIME, RHOPA
Plasmid encoded:	None