| Accession |
MF_00161 |
| Dates |
1-JUN-2001 (Created)
4-SEP-2008 (Last updated, Version 33) |
| Protein name |
| RecName: |
Full=Lipoprotein signal peptidase;
EC=3.4.23.36; |
| AltName: |
Full=Prolipoprotein signal peptidase; |
| AltName: |
Full=Signal peptidase II;
Short=SPase II; |
|
FUNCTION: This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity).
CATALYTIC ACTIVITY: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
PATHWAY: Protein modification; lipoprotein biosynthesis (signal peptide cleavage).
case <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case
SIMILARITY: Belongs to the peptidase A8 family.
| Pfam |
PF01252; Peptidase_A8; 1;
|
| PRINTS |
PR00781; LIPOSIGPTASE; 1;
|
| TIGRFAMs |
TIGR00077; lspA; 1;
|
| PROSITE |
PS00855; SPASE_II; 1;
|
| General |
Transmembrane; -; 4-5; trigger=Yes;
|
case <Property:Membrane=2>
end case
GO:0004190; Molecular function: aspartic-type endopeptidase activity.
GO:0005886; Cellular component: plasma membrane.
| From: LSPA_ECOLI (P00804) |
| Key |
|
From |
|
To |
|
Description |
|
Condition |
|
FTGroup |
| ACT_SITE |
|
114 |
|
114 |
|
By similarity |
|
D |
|
|
| ACT_SITE |
|
141 |
|
141 |
|
By similarity |
|
D |
|
|
| Size range: |
145-304 amino acids |
| Related UniRules: |
None |
| Template: |
P00804 (LSPA_ECOLI); Q45479 (LSPA_BACSU): [Recover all] |
| Scope: |
Bacteria |
| Fusion: |
Nter: <Unknown>; Cter: None |
| Duplicate: |
in LISMO, STAES |
| Plasmid encoded: |
in ARTAU, KLEPN, PSEND, PSEPU, RHOER, SERMA |
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