HAMAP family: MF

General rule information

Accession	MF_00158
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 21)

Data class

Protein

Predictors

HAMAP; MF_00158; [distribution of match scores in UniProtKB];[seed alignment for MF_00158]

Propagated annotation

Identifier, protein and gene names

Identifier

PANC

Protein name

RecName:	Full=Pantothenate synthetase; Short=PS; EC=6.3.2.1;
AltName:	Full=Pantoate--beta-alanine ligase;
AltName:	Full=Pantoate-activating enzyme;

Gene name

panC

Comments

FUNCTION: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity).

CATALYTIC ACTIVITY: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

PATHWAY: Cofactor biosynthesis; pantothenate biosynthesis; pantothenate from beta-alanine and pantoate: step 1/1.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

MISCELLANEOUS: The reaction proceeds by a bi uni uni bi ping pong mechanism (By similarity).

SIMILARITY: Belongs to the pantothenate synthetase family.

Cross-references

Pfam	PF02569; Pantoate_ligase; 1;
TIGRFAMs	TIGR00018; panC; 1;

Keywords

ATP-binding, Cytoplasm, Ligase, Nucleotide-binding, Pantothenate biosynthesis.

Gene Ontology

GO:0004592; Molecular function: pantoate-beta-alanine ligase activity.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Features

`From: PANC_MYCTU (P0A5R0)`
`Key`	`From`	`To`	`Description`	`Condition`	`FTGroup`
`NP_BIND`	`40`	`47`	`ATP (By similarity)`	`M-x(3)-H-x(2)-H`
`NP_BIND`	`158`	`161`	`ATP (By similarity)`	`G-x(2)-D`
`NP_BIND`	`195`	`198`	`ATP (By similarity)`	`x(3)-R`
`ACT_SITE`	`47`	`47`	`Proton donor (By similarity)`	`H`
`BINDING`	`72`	`72`	`Beta-alanine (By similarity)`	`Q`
`BINDING`	`72`	`72`	`Pantoate (By similarity)`	`Q`
`BINDING`	`164`	`164`	`Pantoate (By similarity)`	`Q`
`BINDING (Optional)`	`187`	`187`	`ATP; via amide nitrogen and carbonyl oxygen (By similarity)`	`[VLIGA]`

Additional information

Size range:	251-337 amino acids
Related UniRules:	MF_01349 (PANCY (supersedes the current rule))
Template:	P31663 (PANC_ECOLI); P0A5R0 (PANC_MYCTU); Q9X713 (PANC_CORGL): [Recover all]
Scope:	Bacteria; except Cyanobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BRAJA, FRAAA
Plasmid encoded:	in RHIEC, RHIL3, SILST
Comments:	In Cyanobacteria this protein is fused C-terminally to cytidylate kinase (see Bifunctional pantoate ligase/cytidylate kinase MF_01349). Possible sequence error in STRCO; weird insertion; not shown in alignment.

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