Accession	MF_00150
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 36)

Data class

Protein

Predictors

HAMAP; MF_00150; [distribution of match scores in UniProtKB];[seed alignment for MF_00150]

Identifier

ARGC

Protein name

RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase; Short=AGPR; EC=1.2.1.38; AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase; Short=NAGSA dehydrogenase;

Gene name

argC

Protein name

RecName: Full=N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase; Short=AGPR; EC=1.2.1.38; EC=1.2.1.-; AltName: Full=N-acetyl-glutamate semialdehyde/N-acetyl-aminoadipate semialdehyde dehydrogenase; Short=NAGSA dehydrogenase;

Gene name

argC, lysY

FUNCTION: Involved in both the arginine and lysine biosynthetic pathways (By similarity).

CATALYTIC ACTIVITY: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.

CATALYTIC ACTIVITY: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP(+) + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH.

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Pfam	PF01118; Semialdhyde_dh; 1;
PROSITE	PS01224; ARGC; 1;

Cytoplasm, Amino-acid biosynthesis, Arginine biosynthesis.

Lysine biosynthesis.

Oxidoreductase, NADP.

GO:0003942; Molecular function: N-acetyl-gamma-glutamyl-phosphate reductase activity.
GO:0006526; Biological process: arginine biosynthetic process.

GO:0009085; Biological process: lysine biosynthetic process.

GO:0005737; Cellular component: cytoplasm.

From: ARGC_ECOLI (P11446)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		154		154		By similarity		C

Size range:	308-364 amino acids
Related UniRules:	MF_01110 (ARGC)
Template:	P11446 (ARGC_ECOLI); Q980X1 (ARGC_SULSO): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in LACPL, THETH
Plasmid encoded:	None