Accession	MF_00118
Dates	1-JUN-2001 (Created) 25-SEP-2008 (Last updated, Version 34)

Data class

Protein

Predictors

HAMAP; MF_00118_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00118_B]

Predictors

HAMAP; MF_00118_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00118_A]

Identifier

EFTU

Protein name

RecName: Full=Elongation factor Tu; Short=EF-Tu;

Gene name

tuf

Identifier

EF1A

Protein name

RecName: Full=Elongation factor 1-alpha; Short=EF-1-alpha; AltName: Full=Elongation factor Tu; Short=EF-Tu;

Gene name

tuf

Identifier

EFTU

Protein name

RecName: Full=Elongation factor Tu, chloroplastic; Short=EF-Tu;

Gene name

tufA

FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity).

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast.

SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Pfam	PF00009; GTP_EFTU; 1;
PRINTS	PR00315; ELONGATNFCT; 1;
TIGRFAMs	TIGR00483; EF-1_alpha; 1; TIGR00485; EF-Tu; 1;
PROSITE	PS00301; EFACTOR_GTP; 1;

Acetylation.

Cytoplasm.

Elongation factor, Protein biosynthesis, GTP-binding, Nucleotide-binding.

GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.

GO:0005737; Cellular component: cytoplasm.

GO:0009507; Cellular component: chloroplast.

From: EFTU_ECOLI (P0A6N1)
Key		From		To		Description		Condition		FTGroup
NP_BIND		19		26		GTP (By similarity)		G-[HQ]-[IV]-[DY]-H-G-K-[ST]
NP_BIND		81		85		GTP (By similarity)		D-x-P-G-H
NP_BIND		136		139		GTP (By similarity)		N-K-x-D

Key		From		To		Description		Condition		FTGroup
MOD_RES		314		314		N6-acetyllysine (By similarity)		K

From: EF1A_METJA (Q57770)
Key		From		To		Description		Condition		FTGroup
NP_BIND		14		21		GTP (By similarity)		G-H-[IV]-D-[NHA]-G-K-S
NP_BIND		91		95		GTP (By similarity)		D-x-P-G-H
NP_BIND		149		152		GTP (By similarity)		N-K-M-D

Size range:

389-430 amino acids

Size range:

413-444 amino acids

Related UniRules:	None
Template:	P35021 (EF1A_SULSO); P0A6N1 (EFTU_ECOLI); Q01698 (EFTU_THEAQ); P60338 (EFTU1_THETH); Q57770 (EF1A_METJA): [Recover all]
Scope:	Bacteria Archaea Plastid
Fusion:	Nter: None; Cter: None
Duplicate:	in AQUAE, ECOLI, HAEIN, STRCO, STRRA, THET8
Plasmid encoded:	in SHEB5
Comments:	Duplicated in some but not necessarily all Acidobacteria, Proteobacteria, Alkaliohilus, Clostrium, Chloroflexi, Deinococcus, Magnetococcus, Sphingobacter, Streptomyces, Syntrophobacter. Short versions in EHRRW, VIBVU, and a divergent copy in CHAGL are atypical.