Accession	MF_00116
Dates	1-JUN-2001 (Created) 4-DEC-2008 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00116; [distribution of match scores in UniProtKB];[seed alignment for MF_00116]

Identifier

DUT

Protein name

RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase; Short=dUTPase; EC=3.6.1.23; AltName: Full=dUTP pyrophosphatase;

Gene name

dut

FUNCTION: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).

CATALYTIC ACTIVITY: dUTP + H(2)O = dUMP + diphosphate.

PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

SIMILARITY: Belongs to the dUTPase family.

Pfam	PF00692; dUTPase; 1;
TIGRFAMs	TIGR00576; dut; 1;

Hydrolase, Nucleotide metabolism.

GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.

Size range:	139-185 amino acids
Related UniRules:	None
Template:	P06968 (DUT_ECOLI); P0A552 (DUT_MYCTU): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None