HAMAP family: MF

General rule information

Accession	MF_00115
Dates	1-JUN-2001 (Created) 30-JUN-2008 (Last updated, Version 32)

Data class

Protein

Predictors

HAMAP; MF_00115; [distribution of match scores in UniProtKB];[seed alignment for MF_00115]

Propagated annotation

Identifier, protein and gene names

Identifier

MSCL

Protein name

RecName:

Full=Large-conductance mechanosensitive channel;

Gene name

mscL

Comments

FUNCTION: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity).

SUBUNIT: Homopentamer (By similarity).

case <Property:Membrane=1>

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

end case

SIMILARITY: Belongs to the mscL family.

Cross-references

Pfam	PF01741; MscL; 1;
TIGRFAMs	TIGR00220; mscL; 1;
PROSITE	PS01327; MSCL; 1;
General	Transmembrane; -; 2-3; trigger=Yes;

Keywords

case <Property:Membrane=2>

Cell inner membrane.

end case

Cell membrane, Ionic channel, Ion transport, Membrane, Transmembrane, Transport.

Gene Ontology

GO:0015267; Molecular function: channel activity.
GO:0006810; Biological process: transport.
GO:0005886; Cellular component: plasma membrane.

Additional information

Size range:	116-161 amino acids
Related UniRules:	None
Template:	P0A742 (MSCL_ECOLI); P0A5K8 (MSCL_MYCTU): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in RHILO
Plasmid encoded:	None

View rule in raw text format (no links)