Accession	MF_00111
Dates	1-JUN-2001 (Created) 26-SEP-2008 (Last updated, Version 33)

Data class

Protein

Predictors

HAMAP; MF_00111; [distribution of match scores in UniProtKB];[seed alignment for MF_00111]

Identifier

MURA

Protein name

RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase; EC=2.5.1.7; AltName: Full=Enoylpyruvate transferase; AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase; Short=EPT;

Gene name

murA

FUNCTION: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine (By similarity).

CATALYTIC ACTIVITY: Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.

PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the EPSP synthase family. MurA subfamily.

Pfam	PF00275; EPSP_syntase; 1;
TIGRFAMs	TIGR01072; murA; 1;

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Cytoplasm, Peptidoglycan synthesis, Transferase.

GO:0008760; Molecular function: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: MURA_ECOLI (P0A749)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		115		115		Proton donor (By similarity)		[CD]
BINDING		115		115		Phosphoenolpyruvate (covalent) (By similarity)		C

Size range:	414-465 amino acids
Related UniRules:	None
Template:	P0A749 (MURA_ECOLI); P33038 (MURA_ENTCL): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACC1, BACCR, BACCZ, BACHD, BACHK, BACLD, BACSK, BACSU, CARHZ, CLOAB, CLOPE, CLOTE, ENTFA, GEOKA, LACLA, LACLP, LACSS, LEGPL, LISIN, LISMO, OCEIH, PROMA, RHILO, STAAB, STAHJ, STAS1, STRA1, STRA3, STRA5, STRMU, STRPM, STRPN, STRP1, STRT1, STRT2, SYMTH, THETN
Plasmid encoded:	in SILPO
Comments:	Longer C-terminus in one copy in LEGPL; not included in size range