Accession	MF_00108
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00108; [distribution of match scores in UniProtKB];[seed alignment for MF_00108]

Identifier

ISPD

Protein name

RecName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; EC=2.7.7.60; AltName: Full=4-diphosphocytidyl-2C-methyl-D-erythritol synthase; AltName: Full=MEP cytidylyltransferase; Short=MCT;

Gene name

ispD

FUNCTION: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).

CATALYTIC ACTIVITY: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

PATHWAY: Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via DXP pathway; isopentenyl-PP from 1-deoxy-D-xylulose 5-phosphate: step 2/6.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the ispD family.

Pfam	PF01128; IspD; 1;
TIGRFAMs	TIGR00453; ispD; 1;
PROSITE	PS01295; ISPD; 1;

Isoprene biosynthesis, Nucleotidyltransferase, Transferase.

GO:0050518; Molecular function: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.

From: ISPD_ECOLI (Q46893)
Key		From		To		Description		Condition		FTGroup
SITE		20		20		Transition state stabilizer (By similarity)		R
SITE		27		27		Transition state stabilizer (By similarity)		K
SITE		157		157		Positions MEP for the nucleophilic attack (By similarity)		R
SITE		213		213		Positions MEP for the nucleophilic attack (By similarity)		K

Size range:	211-291 amino acids
Related UniRules:	MF_01520 (ISPDF (supersedes the current rule))
Template:	Q46893 (ISPD_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in LISIN, LISMF, LISMO, STAAB, STAAM, STAAN, STAAW, VIBPA
Plasmid encoded:	None
Comments:	See MF_01520 for bifunctional ispDF