Accession	MF_00104
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00104; [distribution of match scores in UniProtKB];[seed alignment for MF_00104]

Identifier

RNC

Protein name

RecName: Full=Ribonuclease 3; EC=3.1.26.3; AltName: Full=Ribonuclease III; Short=RNase III;

Gene name

rnc

FUNCTION: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs (By similarity).

CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphomonoester.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.

SIMILARITY: Contains 1 RNase III domain.

Pfam	PF00035; dsrm; 1; PF00636; Ribonuclease_3; 1;
PROSITE	PS50137; DS_RBD; 1; trigger=PRU00266; PS00517; RNASE_3_1; 1; PS50142; RNASE_3_2; 1; trigger=PRU00177;

Cytoplasm, Hydrolase, Nuclease, Endonuclease.

RNA-binding.

GO:0004525; Molecular function: ribonuclease III activity.
GO:0006397; Biological process: mRNA processing.
GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.

Size range:	221-311 amino acids
Related UniRules:	None
Template:	P0A7Y0 (RNC_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	MYCGE and MYCPN lack the DRBM domain