Accession	MF_00102
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00102; [distribution of match scores in UniProtKB];[seed alignment for MF_00102]

Identifier

DAPB

Protein name

RecName: Full=Dihydrodipicolinate reductase; Short=DHPR; EC=1.3.1.26;

Gene name

dapB

CATALYTIC ACTIVITY: 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the dihydrodipicolinate reductase family.

Pfam	PF01113; DapB; 1;
TIGRFAMs	TIGR00036; dapB; 1;
PROSITE	PS01298; DAPB; 1;

Cytoplasm, Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Oxidoreductase, NADP.

GO:0008839; Molecular function: dihydrodipicolinate reductase activity.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0005737; Cellular component: cytoplasm.

Size range:	216-283 amino acids
Related UniRules:	None
Template:	P04036 (DAPB_ECOLI); P72024 (DAPB_MYCTU): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in RHILO
Plasmid encoded:	in RHIME
Comments:	MYCBO strain BCG seems to originate from a different bacterial species; its sequence is too divergent to that of MYCBO strain AF2122/97 and MYCTU