Accession	MF_00082
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 43)

Data class

Protein

Predictors

HAMAP; MF_00082_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00082_B]

Predictors

HAMAP; MF_00082_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00082_A]

Identifier

ARGB

Protein name

RecName: Full=Acetylglutamate kinase; EC=2.7.2.8; AltName: Full=NAG kinase; Short=AGK; AltName: Full=N-acetyl-L-glutamate 5-phosphotransferase;

Gene name

argB

Protein name

RecName: Full=Acetylglutamate/acetylaminoadipate kinase; EC=2.7.2.8; EC=2.7.2.-; AltName: Full=NAG kinase; Short=AGK; AltName: Full=N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase;

Gene name

argB, lysZ

FUNCTION: Involved in both the arginine and lysine biosynthetic pathways (By similarity).

CATALYTIC ACTIVITY: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.

CATALYTIC ACTIVITY: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate.

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.

SUBUNIT: Homodimer (By similarity).

SUBUNIT: Homohexamer (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast.

SUBCELLULAR LOCATION: Cytoplasm (Probable).

SIMILARITY: Belongs to the acetylglutamate kinase family.

Pfam	PF00696; aakinase; 1;
TIGRFAMs	TIGR00761; argB; 1;

Cytoplasm.

Amino-acid biosynthesis, Arginine biosynthesis, ATP-binding.

Lysine biosynthesis.

Nucleotide-binding, Transferase, Kinase.

GO:0003991; Molecular function: acetylglutamate kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.

GO:0009085; Biological process: lysine biosynthetic process.

GO:0009507; Cellular component: chloroplast.

GO:0005737; Cellular component: cytoplasm.

From: ARGB_ECOLI (P0A6C8)
Key		From		To		Description		Condition		FTGroup
NP_BIND		181		186		ATP (By similarity)		D-[VI]-S-[GS]-I-L
NP_BIND		209		211		ATP (By similarity)		I-I-T

Key		From		To		Description		Condition		FTGroup
REGION		44		45		Substrate binding (By similarity)		[GA]-[GSA]
BINDING		66		66		Substrate (By similarity)		R
BINDING		158		158		Substrate (By similarity)		N
SITE		8		8		Transition state stabilizer (By similarity)		K
SITE		217		217		Transition state stabilizer (By similarity)		K

From: ARGB_SULSO (Q980X0)
Key		From		To		Description		Condition		FTGroup
REGION		35		36		Substrate binding (By similarity)		G-[GS]
BINDING		62		62		Substrate (By similarity)		R
BINDING		167		167		Substrate (By similarity)		N
SITE		5		5		Transition state stabilizer (By similarity)		K
SITE		224		224		Transition state stabilizer (By similarity)		K

Size range:	244-362 amino acids
Related UniRules:	None
Template:	P0A6C8 (ARGB_ECOLI); Q9HTN2 (ARGB_PSEAE); Q9X2A4 (ARGB_THEMA); Q980X0 (ARGB_SULSO); P0A4Y6 (ARGB_MYCTU): [Recover all]
Scope:	Bacteria Archaea Plastid
Fusion:	Nter: None; Cter: <Unknown>
Duplicate:	None
Plasmid encoded:	None
Comments:	There are divergent sequences in THETH and DEIRA which could be something else than argB