HAMAP family: MF

General rule information

Accession	MF_00058
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 12)

Data class

Protein

Predictors

HAMAP; MF_00058; [distribution of match scores in UniProtKB];[seed alignment for MF_00058]

Propagated annotation

Identifier, protein and gene names

Identifier

MTD

Protein name

RecName:	Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase; Short=MTD; EC=1.5.99.9;
AltName:	Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase;

Gene name

mtd

Comments

case <Property:METHANOG>

FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT (By similarity).

end case

case not <Property:METHANOG>

FUNCTION: Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+) (By similarity).

end case

CATALYTIC ACTIVITY: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420.

case <Property:METHANOG>

PATHWAY: One-carbon metabolism; methanogenesis from carbone dioxide; 5,10-methylene-H(4)MPT from 5,10-methenyl-H(4)MPT (cofactor F420 route): step 1/1.

end case

case <OC:Archaeoglobales>

PATHWAY: Metabolic intermediate metabolism; lactic acid oxidation.

end case

SIMILARITY: Belongs to the MTD family.

Cross-references

Pfam	PF01993; MTD; 1;

Keywords

case <Property:METHANOG>

Methanogenesis.

end case

One-carbon metabolism, Oxidoreductase.

Gene Ontology

GO:0030268; Molecular function: methylenetetrahydromethanopterin dehydrogenase activity.
GO:0006730; Biological process: one-carbon compound metabolic process.

case <Property:METHANOG>

GO:0015948; Biological process: methanogenesis.

end case

Additional information

Size range:	273-283 amino acids
Related UniRules:	None
Template:	P94951 (MTD_METKA); O29544 (MTD_ARCFU): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None

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