Accession	MF_00056
Dates	1-JUN-2001 (Created) 23-SEP-2008 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00056; [distribution of match scores in UniProtKB];[seed alignment for MF_00056]

Identifier

KDSA

Protein name

RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase; EC=2.5.1.55; AltName: Full=Phospho-2-dehydro-3-deoxyoctonate aldolase; AltName: Full=3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; AltName: Full=KDO-8-phosphate synthetase; Short=KDO 8-P synthase; Short=KDOPS;

Gene name

kdsA

CATALYTIC ACTIVITY: Phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate.

PATHWAY: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.

PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the kdsA family.

Pfam	PF00793; DAHP_synth_1; 1;
TIGRFAMs	TIGR01362; KDO8P_synth; 1;

Cytoplasm, Lipopolysaccharide biosynthesis, Transferase.

GO:0008676; Molecular function: 3-deoxy-8-phosphooctulonate synthase activity.
GO:0009103; Biological process: lipopolysaccharide biosynthetic process.
GO:0019294; Biological process: ketodeoxyoctanoate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	263-290 amino acids
Related UniRules:	None
Template:	P0A715 (KDSA_ECOLI); O66496 (KDSA_AQUAE): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BURPS, PSEPK
Plasmid encoded:	None