Accession	MF_00051
Dates	1-JUN-2001 (Created) 4-MAY-2009 (Last updated, Version 33)

Data class

Protein

Predictors

HAMAP; MF_00051_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00051_B]

Predictors

HAMAP; MF_00051_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00051_A]

Identifier

GLYA

Protein name

RecName: Full=Serine hydroxymethyltransferase; Short=Serine methylase; Short=SHMT; EC=2.1.2.1;

Gene name

glyA

FUNCTION: Interconversion of serine and glycine (By similarity).

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: One-carbon metabolism; tetrahydrofolate pathway.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the SHMT family.

Pfam	PF00464; SHMT; 1;
PROSITE	PS00096; SHMT; 1;

Acetylation.

Cytoplasm, One-carbon metabolism, Pyridoxal phosphate, Transferase.

GO:0004372; Molecular function: glycine hydroxymethyltransferase activity.
GO:0006730; Biological process: one-carbon compound metabolic process.
GO:0009069; Biological process: serine family amino acid metabolic process.
GO:0005737; Cellular component: cytoplasm.

From: GLYA_ECOLI (P0A825)
Key		From		To		Description		Condition		FTGroup
MOD_RES		229		229		N6-(pyridoxal phosphate)lysine (By similarity)		K

Key		From		To		Description		Condition		FTGroup
MOD_RES		54		54		N6-acetyllysine (By similarity)		K
MOD_RES		250		250		N6-acetyllysine (By similarity)		K
MOD_RES		285		285		N6-acetyllysine (By similarity)		K
MOD_RES		354		354		N6-acetyllysine (By similarity)		K
MOD_RES		375		375		N6-acetyllysine (By similarity)		K

From: GLYA_METJA (Q58992)
Key		From		To		Description		Condition		FTGroup
MOD_RES		226		226		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:

406-574 amino acids

Size range:

412-442 amino acids

Related UniRules:	None
Template:	P0A825 (GLYA_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in AGRT5, BORBR, BORPA, BURMA, BURP1, BURPS, BURS3, BURTA, COLP3, ERWCT, HAHCH, MYCBO, MYCTU, PHOPR, PSE14, PSEAE, PSEF5, PSEPF, PSEPK, PSESM, PSEU2, RALEJ, RALSO, RHILO, RHIME, RHOPA, RHORT, SILPO, SULDN, VIBCH, VIBPA, VIBVU, VIBVY
Plasmid encoded:	None
Comments:	Possible wrong start in ARCFU and HALSA. Possible C-terminal problem in TREPA.